Suzetrigine for the Treatment of Acute Pain: Reply
Abstract
In Reply: We thank Milam et al., Siddiqui et al., and Xiang et al. for their commentary.1–3 The phase 3 randomized controlled trials of suzetrigine for moderate-to-severe acute pain after abdominoplasty and bunionectomy had significant representation of Black/African American (abdominoplasty, 299 of 1,118; bunionectomy, 260 of 1,073) and Hispanic/Latino participants (abdominoplasty, 380 of 1,118; bunionectomy, 364 of 1,073).4 While our studies were not designed to detect differences within subgroups, ad hoc analyses demonstrated that the efficacy of suzetrigine compared to placebo (measured by sum of the pain intensity difference in numeric pain rating scale from 0 to 48 h [SPID48], primary endpoint) was generally consistent across racial and ethnic subgroups. In a study by McCoun et al., involving diverse surgical and nonsurgical pain conditions, participants’ perception of suzetrigine’s effectiveness in managing pain at the end of treatment (assessed by the proportion of participants reporting good, very good, or excellent pain relief) was similar among White (84%, 180 of 214), Black/African American (79%, 27 of 34), and Hispanic/Latino (83%, 90 of 108) participants.5 With regard to sex, our bunionectomy study, which enrolled a sufficient number of males, showed that SPID48 was similar in male and female participants.4 Further, suzetrigine’s effectiveness was similar in male (80%, 66 of 83) and female (85%, 147 of 173) participants in the McCoun et al. study.5 Literature…
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design. Reported size: 3,000 participants or records.
Read the paper
Related studies
- Noninvasive and Point-of-Care Surface-Enhanced Raman Scattering (SERS)-Based Breathalyzer for Mass Screening of Coronavirus Disease 2019 (COVID-19) under 5 min
- De Novo Transcriptome Analysis and Detection of Antimicrobial Peptides of the American Cockroach Periplaneta americana (Linnaeus)
- Molecular Characterization and Expression Profiling of Tomato GRF Transcription Factor Family Genes in Response to Abiotic Stresses and Phytohormones
- Assembly of Tight Junction Strands: Claudin-10b and Claudin-3 Form Homo Tetrameric Building Blocks that Polymerise in a Channel-Independent Manner
- Update of the Pompe variant database for the prediction of clinical phenotypes: Novel disease‐associated variants, common sequence variants, and results from newborn screening
- Machine Learning-Based SERS Chemical Space for Two-Way Prediction of Structures and Spectra of Untrained Molecules
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.