Polycystic Ovary Syndrome: A Review on Present Complication and Future Threat in Women's Health
Abstract
Polycystic ovary syndrome (PCOS) is a complicated disease connected to an endocrine condition. The persistent hormonal imbalance causes complications including numerous cysts and irregular menstruation, which ultimately makes it challenging for women to get pregnant. According to an estimation by the World Health Organization, worldwide, over 116 million women are affected by PCOS (3.4%). The Lifestyle modification and dietary control are the most powerful therapeutic strategies in females to control PCOS complications, in a shame the fresh environmental assets like air, radiations, water play a crucial role in prevention and therapy. The imbalance of hormones is responsible for neuroendocrine, genetics, obesity, and lifestyle-based problems that lead to the formation of PCOS. The excess formation of androgen, insufficient insulin sensitivity, and maturing ovarian follicles are the primary pathophysiological features of PCOS that increase the risk of associated disorders. As a result, this review emphasized the overview PCOS and associated complications. The review focused on the pathophysiology, signalling pathways, GPCR/camp/PKA pathway and lifestyle management to control the PCOS symptoms and disorders. The ovarian responsiveness and pathophysiology therapies are discussed in this review to emphasize the details physiology of PCOS disease for treatment and interventions. The present review tried to connect the dots of the underlying mechanism of action of hormones to…
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