Proton pump inhibitor dexlansoprazole in pure form and pharmaceutical formulations using alizarin derivatives
Abstract
Two simple, sensitive, accurate, and precise spectrophotometric methods have been developed and validated for the determination of proton pump inhibitor dexlansoprazole (DXL) in pure form and pharmaceutical formulations. The method was based on the formation of charge transfer complex between DXL and quinalizarin (Quinz) and alizarin red S (ARS) as chromogenic reagents in methanol which showed an absorption maximum at 558 and 542 nm using Quinz and ARS, respectively. The optimization of the reaction conditions such as the type of solvent, reagent concentration and reaction time were investigated. Under the optimum conditions, beer’s law is obeyed in the concentration ranges 1.0-12 and 1.0-16 μg mL-1 using Quinz and ARS, respectively with good correlation coefficient (r2 ≥ 0.9994) and with a relative standard deviation (RSD% ≤ 1.11). The molar absorptivity, Sandell sensitivity, detection and quantification limits are also calculated. The methods were successfully applied to the determination of DXL in its pharmaceutical formulations and the validity assesses by applying the standard addition technique. Results obtained by the proposed methods for the pure DXL and commercial tablets agreed well with those obtained by the reported method.
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