Dexlansoprazole exposure and collagenous colitis: A case series
Abstract
Microscopic colitis, comprised of collagenous colitis and lymphocytic colitis, based on histopathologic findings, is a complex condition typically affecting elderly patients and rooted in genetic, environmental, and chemical exposures including pharmaceutical compounds. This report describes 4 patients who developed symptomatic and histopathologic collagenous colitis after exposure to dexlansoprazole. No prior association between the development of microscopic colitis and exposure to this proton pump inhibitor has been described. Clinical details and outcomes are documented, and the possible association discussed. The observations are relevant to ongoing use of this medication in clinical practice. *Correspondence to: Gilbert M Wilcox, Portland Gastroenterology Center 161 Marginal Way Portland, ME 04101, USA, E-mail: [email protected] Received: August 15, 2018; Accepted: September 05, 2018; Published: September 10, 2018 Introduction Collagenous and lymphocytic colitis are chronic inflammatory diseases of the colon first described in 1976-1980 and characterized by watery diarrhea with normal appearing mucosa on endoscopic examination [1-4]. Mucosal biopsy required for diagnosis reveals a chronic inflammatory process with lymphocytic infiltration, subepithelial collagen deposition, or both. The two pathologic processes are often called microscopic colitis (MC). As described in early reports, the disease can occur as a primary event of variable severity, but it can also be…
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Evidence Hub reads this as a case series, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
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