Is Long-Term Proton Pump Inhibitor Use a Cause of Leaky Gut Syndrome: A Cross-Sectional Case-Control Study
Abstract
Our study aims to investigate the effect of bacterial overgrowth induced by long-term PPI use on zonulin levels.
Conditions: Proton Pump Inhibitor Adverse Reaction.
Primary outcome: Zonulin levels in long-term proton pump inhibitor users.
Enrollment: 75 participants.
How strong is the evidence?
Evidence Hub reads this as a clinical trial, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 75 participants or records.
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