Formulation and Evaluation of Dexlansoprazole Floating Tablets
Abstract
The purpose of this research was to prepare a Dexlansoprazole GastroRetentive Drug Delivery System. Dexlansoprazole with gas propellantwith controlled release can be developed to increase the time of gastricpermanence and therefore increase its bioavailability. The formulatedfloating tablets have given satisfactory results for various postcompressive parameters such as hardness, friability, thickness, weightvariation and uniformity of the content. Sodium bicarbonate has apredominant effect on the buoyancy delay time, while chitosan has apredominant effect on the total flotation time and drug release. Carbopolalso shows a significant effect in drug release. Sodium alginate andxanthan gum gave additional adhesive properties and helped maintain theintegrity of the tablet. The swelling index has a significant effect on drugrelease.Formulations F2 and F4 showed a higher rate of swelling than others. In vitro release rate studies showedthat maximum drug release was observed in F2 and F2 formulations for up to 12 hours. TLC studiesrevealed that there was no interaction between dexlansoprazole and the polymers used. The data obtainedfrom in vitro dissolution studies were fitted in different models viz. zero order, first order andKorsemeyer’s equation. The zero order plots were found to be fairly linear as indicated by their highregression values (r2 = 0.979 to 0.996). From the study it is evident that the floating tablets based onDexlansoprazole with gas propellant with controlled…
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