Formulation of Dual Delayed release pellets using Fluidized bed processor
Abstract
A new method of oral drug administration called dual delayed release (DDR) formulations releases the medication in two independent pulses separated by a predetermined lag time.For medications with short half-lives, pH-dependent solubility, or therapeutic needs for prolonged release, this approach is very beneficial.Acid-related illnesses are commonly treated with DDR systems; the most well-known example is dexlansoprazole.The ideas, formulation techniques, core material selection, and coating polymer selection are all summed up in this summary.Various techniques for stacking pellets, a brief explanation of the fluidized bed process, and variables influencing the creation of granules and the granulation process, along with a description of the variables connected to the instrument and the material.
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