Cocrystallization: An Approach to Improve Bioavailability by Altering Physicochemical Properties of Poorly Soluble API’s
Abstract
Biopharmaceutics Classification System (BCS) class II and IV suffer from poor aqueous solubility and hence low oral bioavailability during formulation development.Cocrystallization is one of the latest approaches based on crystal engineering and has been used to enhance specific physicochemical parameters like melting point, solubility, dissolution rate, chemical stability, and tablet ability of the active pharmaceutical ingredients.Cocrystal is crystalline single-state material composed of two or more than two different molecular association systems of active pharmaceutical ingredients (API) with a stoichiometric ratio of a pharmaceutically acceptable coformer incorporated within the crystal lattice.Various methods have been used for the preparation of cocrystals such as grinding, solvent evaporation, hot-melt extrusion, spray drying, etc.Currently, cocrystal gained exciting opportunities in the drug discovery and development of new medicine by improving the poor physicochemical properties of APIs.There are a huge number of documents, literature available on cocrystals.However, there is a shortage of reviews on the selection of Coformer.In this work, attempts have been made to fill this gap.This review also focuses on an overview of pharmaceutical cocrystal and their method of preparation, selection of coformers with the improved pharmaceutical application of cocrystal.
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