Formulation and evaluation of effervescent granules of Ranitidine Hydrochloride
Abstract
Objective: Peptic ulcer causes lesions in the stomach and oesophagus.The present work is aimed to develop the effervescent granules of Ranitidine Hydrochloride to relieve the pain instantly.: Effervescent Materials and methods granules were prepared by dry granulation technique using disodium citrate, sodium saccharin, polyvinyl pyrrolidine, glycine, sodium benzoate, sodium bicarbonate.The prepared granules were evaluated for angle of repose, bulk and tapped density, carr's index and hausner's ratio, in-vitro drug release studies and DSC.The angle of repose for Results: formulations F1-F6 was obtained in the range of 32.38°±0.34 to 37.65°±0.53which indicates the passible flow property of the formulation.Bulk density and Tapped density for formulations F1-F6 was obtained in the range of 0.42 ± 0.01 to 0.46 ±0.02 and 0.51±0.02 to 0.58±0.02respectively.The Carr's Index and Hausners Ratio for the formulations F1-F6 was obtained in a range of 15.85±2.97 to 22.4 ± 2.88 and 1.256±0.05to 1.196±0.04which indicates good flow property of the given formulation.Percentage release of the drug for the formulations F1-F6 was obtained in a range of 50% to 91%.Among all formulations F4 formulation has highest amount of drug release compared to other Conclusion: formulations.Hence it was considered as promising formulation for further studies.DSC of F4 formulation was found be at 184.5 which indicates that there is no incompatibility between the drug and excipients.
Read the paper
Related studies
- Improving sleep quality leads to better mental health: A meta-analysis of randomised controlled trials
- Tocilizumab in patients with severe COVID-19: a retrospective cohort study
- A new aging measure captures morbidity and mortality risk across diverse subpopulations from NHANES IV: A cohort study
- Fruit, vegetable, and legume intake, and cardiovascular disease and deaths in 18 countries (PURE): a prospective cohort study
- Are noise and air pollution related to the incidence of dementia? A cohort study in London, England
- Long COVID symptoms and duration in SARS-CoV-2 positive children — a nationwide cohort study
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.