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Neurological Manifestations Associated With Hypomagnesemia Due to Proton-Pump Inhibitors: A Case Series

James L, Rajan G, Devarajan D, Mohan A

Cureus, 2025

Abstract

We discuss a case series that explores the presentation and diagnostic challenges of three elderly male patients with hypomagnesemia. This series highlights the association between hypomagnesemia and hypocalcemia, both of which contribute to neurological symptoms. Proton-pump inhibitors, when taken for a long duration, are known to cause hypomagnesemia. This series also emphasizes the reversible neurological syndromes in patients with hypomagnesemia due to prolonged pantoprazole intake.

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Evidence Hub reads this as a case series, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.

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