Comparison of oral efficacy between PPIs and H2RAs in subjects for prevention and monitoring of peptic ulcerassociated recurrence rates from 1985 to 2021: A systematic review and meta-analysis
Abstract
Currently, although there are many randomized controlled trials comparing the effectiveness of proton pump inhibitors and H2-antihistamines in relation to peptic ulcer disease, meta-analytical studies on this topic are still limited and conclusions have not come to consensus. Therefore, a meta-analysis of randomized controlled trials evaluated by the Cochrane Collaboration tool is essential. From January 1st, 1985, to May 31st, 2022, the study was carried out on three databases: Pubmed, Cochrane, and Embase. Statistics are expressed as odds ratios, with confidence intervals of 95 %, and a random effects model is used. Results: Proton pump inhibitors increase the effectiveness of treatment more than H2-antihistamines. Specifically, on prevention subjects = 0.15 (95 % CI: 0.05-0.44), patients who are monitored for relapse rates without medication = 0.92 (95 % CI: 0.75-1.14), and with medication = 0.50 (95 % CI: 0.31-0.80). In conclusion, proton pump inhibitors are the first-line medicine for ulcer prevention and post-healing monitoring. ® 2022 Journal of Science and Technology - NTTU
How strong is the evidence?
Evidence Hub reads this as a meta-analysis, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid.
Read the paper
Related studies
- Improving sleep quality leads to better mental health: A meta-analysis of randomised controlled trials
- Tocilizumab in patients with severe COVID-19: a retrospective cohort study
- A new aging measure captures morbidity and mortality risk across diverse subpopulations from NHANES IV: A cohort study
- Fruit, vegetable, and legume intake, and cardiovascular disease and deaths in 18 countries (PURE): a prospective cohort study
- Are noise and air pollution related to the incidence of dementia? A cohort study in London, England
- Long COVID symptoms and duration in SARS-CoV-2 positive children — a nationwide cohort study
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.