Healthcare Resource Utilization and Costs of Newly Treated GERD Patients Initiating Therapy with Dexlansoprazole and Esomeprazole in the United States: 1603
Abstract
Purpose: To describe the healthcare resource utilization and costs of newly treated patients with gastroesophageal reflux disease (GERD) who are initiating treatment with dexlansoprazole (DEX) or esomeprazole (ESO). Methods: Adults with at least one prescription claim for DEX or ESO between 1/1/2009 and 12/31/2010 (index event), ≥12 months of pre- and post-index continuous health plan and pharmacy benefit enrollment, and a diagnosis of GERD on ≥1 inpatient or non-diagnostic outpatient medical claim (ICD-9-CM 530.10, 530.11, 530.12, 530.13, 530.19, 530.81,787.1x) in the pre- or post-index period were identified from the linked MarketScan and GE Centricity research databases. Patients with PPI or H2RA treatment in the pre-index period were excluded, as were those with an indication of pregnancy at any time during the study period. Total all-cause and GERD-related utilization and costs in the 12-month post-index period were calculated. Generalized linear modeling was used to estimate adjusted costs for the two groups, controlling for differences in demographic (i.e., age, sex, region) and clinical characteristics (e.g., pre-index comorbid burden, GERD diagnosis and GERD-related comorbidities, and index dose level). Results: 965 and 4,749 newly treated patients initiating therapy with DEX (age = 49.0±13.0; 67.2% female) and ESO (age = 50.7±13.4; 64.1% female), respectively, were identified. Patients treated with DEX had a lower mean Charlson Comorbidity Index score than patients…
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