A Study of Acute Renal Failure in the Users of Proton Pump Inhibitors
Abstract
Background: Proton pump inhibitors are one of the most common classes of medications that act by inhibiting gastric H+/K+ adenosine triphosphatase via covalent binding to the cysteine residues of the proton pump, they provide the most potent acid suppression available. Lansoprazole, pantoprazole, and dexlansoprazole have the greatest bioavailability and achieve the highest plasma levels. Rabeprazole is the most acid-labile PPI and therefore the most potent, whereas pantoprazole is the least reactive and therefore the least potent Patients and methods: Research data were collected from Al-zahraa teaching hospital/ Wasit province and Morgan teaching hospital/ Babylon province, they include patients with acute renal failure who used/ using proton pump inhibitors compared with those do not use proton pump inhibitors to know the probable relation between acute renal failure and the use of proton pump inhibitors. Results and discussion: Results showed that only 30 patients of 120 patients with acute renal failure consult the hospital were PPIs users, this may refer to presence of a relationship between proton pump inhibitor and acute Renal failure . Previous studies in this field referred to a similar relationship, a case reports and a recent case series implicating these drugs in acute interstitial nephritis (AIN) and progression to acute renal failure.
How strong is the evidence?
Evidence Hub reads this as a case series, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health. Reported size: 120 participants or records.
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