Comparative and Optimization of administration of Dexlansorazole through nasogastric tubes using an oral liquid vehicle as a suspending agent
Abstract
1.0 INTRODUCTION Proton pump inhibitors (PPIs) are widely used for the treatment of various acid-related disorders. For intensive care patients Stress-induced gastrointestinal tract bleeding (SGIB) is common, Dexlansoprazole is a PPI that suppresses gastric acid secretion by specific inhibition of the (H+,K+)-ATPase in the gastric parietal cell. By acting specifically on the proton pump, dexlansoprazole blocks the final step of acid production, and reduces the associated mortality. The PPIs are sensitive to gastric acid and are formulated to resist breakdown in the stomach and favour intestinal absorption [1-5]. The intensive care patients are unable to swallow for this reason, PPIs have to be administered by gastric tube after dispersion of pellets or pellets in water, or in some fruit juices [6-7]. A number of studies have already been conducted on the administration of omeprazole [6-10], lansoprazole [6,9-13] through nasogastric tubes. The objective of the study was to compare the suitability of administration of dexlansoprazole delayed release capsules 60 mg through nasogastric (NG) tube 16F. In this study, mainly we observe optimum medium for delivery, mode of administration and the behaviour of the enteric coated pellets when administered through nasogastric tubes 16F. These experimental conditions as close as possible to clinical practice.
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