Formulation, development and evaluation of floating microspheres of antiulcer drug using novel synthetic and natural polymers
Abstract
\n\nThe aim of this work was to develop natural and synthetic polymer based microspheres of Dexlansoprazole in different drug-to-polymer ratios to avoid the dose frequency of drug. HPMC, EC, and Guar gum microspheres have outstanding floating capabilities, according to in vivo and in vitro buoyancy experiments. The result indicates that with an increase in the concentration of polymers, HPMC, EC and Guar gum slight decrease the floating time. Formulations F4 of prepared microspheres were found to be the best compare to other formulation. The Floating Lag Time (Sec.) lag time of formulation F4 was also found less (52±6), compare to other formulation.\n\nThe drug release from the floating microspheres was sufficiently sustained, and zero order drug diffusion was verified. Dexlansoprazole floating microspheres may thus offer a practical dose form for providing the optimum results in terms of flow, release, and floating characteristics. Further research is required to determine whether they have the ability to increase human Dexlansoprazole bioavailability.\n\nKey words: Dexlansoprazole, Microspheres, Natural and synthetic polymer, Formulation, Evaluation.
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