Comparative studies on characterization and effectiveness of various alginate-based raft-forming antacid products
Abstract
Background: Gastroesophageal reflux disease develops from exposure of the esophagus to acidic refluxate from the stomach and duodenal bile. While a floating raft, in which calcium carbonate was the main antacid ingredient, is formed on top of the stomach fluid to provide a physical barrier against acid gastroesophageal reflux after ingesting alginate-based antacid products. Objective: This work aimed to test in vitro effectiveness of five alginate suspensions commercially available in the Thai market to understand their characteristics and behaviors in gastric conditions mimicking the human stomach. Methods: Five commercial alginate suspensions were tested under simulated gastric conditions (0.1 N HCl, 37 °C). Raft formation was assessed by recording onset time, volume, mass, and buoyancy. Raft strength was quantified using a texture analyzer with a penetration probe, while porosity was examined visually. Acid neutralization capacity (ANC) was measured by titration against 0.1 N HCl to pH 3.0, and neutralization duration was monitored over time. Correlations between raft characteristics and ANC were analyzed. Results: Rafts of products formed voluminously (64.9-83.8 mL, 39.8-46.4 g), porous and floating rafts within 0.4-6.3 min. Raft strength and neutralization duration was in the range of 13.3-29.9 g and 24-46 min, respectively. Marked differences were not evident in the acid neutralization capacity (ANC) values of the products (8.8-9.9 mEq). No correlation was observed…
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