Medical Therapy for Active Peptic Ulcer Disease
Abstract
Peptic ulcers occur when the damaging effects of acid and pepsin exceed the body's restorative processes that promote mucosal integrity and repair. Several factors have been identified that can contribute to the development of peptic ulcers, including excessive gastric acid secretion, the use of nonsteroidal anti-inflammatory drugs (NSAIDs), infection with Helicobacter pylori, and impaired mucosal bicarbonate secretion. Over time, our understanding of ulcer pathogenesis has increased, leading to the development of various effective therapeutic agents with different mechanisms of action. The aim of this review was to understand the medical therapy for active peptic ulcer disease. The first-line treatment for peptic ulcer disease involves a combination of medications to reduce gastric acid production, protect and repair tissues, and eliminate underlying bacterial infections, particularly Helicobacter pylori. Antibiotics such as doxycycline, metronidazole, clarithromycin, and amoxicillin are prescribed to target and eradicate bacterial infections. Cyto-protective agents, including sucralfate, misoprostol, and bismuth subsalicylate, are used to coat and protect the gastrointestinal lining, aiding in healing. Histamine receptor blockers like famotidine, cimetidine, and nizatidine, as well as proton pump inhibitors such as esomeprazole, dexlansoprazole, lansoprazole, omeprazole, pantoprazole, and rabeprazole, are employed to reduce stomach acid production and foster mucous lining…
Read the paper
Related studies
- Improving sleep quality leads to better mental health: A meta-analysis of randomised controlled trials
- Tocilizumab in patients with severe COVID-19: a retrospective cohort study
- A new aging measure captures morbidity and mortality risk across diverse subpopulations from NHANES IV: A cohort study
- Fruit, vegetable, and legume intake, and cardiovascular disease and deaths in 18 countries (PURE): a prospective cohort study
- Are noise and air pollution related to the incidence of dementia? A cohort study in London, England
- Long COVID symptoms and duration in SARS-CoV-2 positive children — a nationwide cohort study
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.