S2322 Factors Associated With Therapeutic Failure in the Eradication of Helicobacter pylori in a Population in Northeast Colombia
Abstract
Introduction: Globally, gastric cancer ranked sixth in incidence and seventh in mortality in 2022 (GLOBOCAN). In Colombia's northeastern region, it held the third highest incidence in 2022. Helicobacter pylori infection is the primary risk factor for gastric cancer development. Understanding factors influencing treatment failure of H. pylori eradication is crucial. This study aimed to evaluate factors associated with therapy failure in a northeastern Colombian population. Methods: This retrospective cohort study utilized anonymized secondary data from a quality control database for Gastrocal endoscopic procedures performed between January and June 2023. Pharmacological adherence (PA) to the H. pylori eradication regimen was assessed using the Morisky-Green Scale. Treatment failure was defined as a positive carbon-14 urea breath test result at 6 weeks post-antibiotic therapy completion. Relative risk (RR) with 95% confidence intervals (CI) and P-values were employed as effect measures. Statistical analysis was performed using STATA/SE v 14.0. Results: A total of 87 patients were analyzed, with a mean age of 51 ± 14 years. The majority (62.07%) were women, and chronic superficial antral gastritis (73.56%) was the most frequent endoscopic finding. Eradication failure was observed in 16.1% of patients. Among those failing therapy, 40% had received one prior eradication regimen, and 70% had received 2 or more. Significantly lower eradication success rates were associated with…
How strong is the evidence?
Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 87 participants or records.
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