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Association of cumulative exposure to cholesterol, high‐density lipoprotein, and glucose index with the risk of cardiovascular disease and all‐cause mortality: A longitudinal cohort study

Ruobing Tian, Xue Tian, Shuo-Hua Chen, Xinya Li, Manqi Zheng, Shouling Wu, Anxin Wang, Rui-Le Fang

Diabetes, obesity and metabolism, 2025

15 citations

Abstract

An innovative insulin resistance (IR)‐related index of cholesterol, high‐density lipoprotein, and glucose (CHG) has been linked to cardiovascular disease (CVD) risk, but there is limited evidence for the effect of a long‐term pattern of CHG on CVD and all‐cause mortality. This study aimed to examine the associations between cumulative CHG and the occurrence of CVD and all‐cause mortality.

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Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence.

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