Effective PPI Therapy: Ensuring Appropriate Dosage of PPI in Patients with Different Comorbidities in Medicine, Surgery and Gastroenterology Ward
Abstract
Background: Proton pump inhibitors (PPIs) are widely prescribed medications used to treat conditions related to excessive stomach acid, such as gastroesophageal reflux disease (GERD), peptic ulcers, and Zollinger-Ellison syndrome. Despite their efficacy in managing acid-related disorders, the appropriate use of PPIs, particularly concerning the correct dosage remains a critical issue in clinical practice. Objective: This study aimed to assess the effectiveness of PPI therapy by ensuring appropriate dosage of PPI in patients with different comorbidities in medicine, surgery, and gastroenterology wards in Dhaka Medical College Hospital. Methods: This cross-sectional observational study was conducted at the Department of Pharmacology and Therapeutics, Dhaka Medical College, Dhaka, from July 2019 to June 2020. A total of 600 patients were selected as study subjects by purposive sampling technique. Data were collected and evaluated considering USFDA-approved indications, and the systematic review by Scarpignato et al. recommendations. Data were analyzed using descriptive statistics. Analysis of data was carried out by using Statistical Package for Social Science (SPSS) 22.0 for Windows. Results: Among 255 patients, who were prescribed PPIs for an appropriate indication, 129 (50.6%) patients were given PPIs in an appropriate dose, whereas the dose was inappropriate in 126 (49.4%) patients. The appropriate dose was followed mostly in the gastroenterology department (83.1%),…
How strong is the evidence?
Evidence Hub reads this as a cross-sectional, done in people. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause. Reported size: 600 participants or records.
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