Patient-centered insights into the USE, prevalence and awareness of side effects of proton pump inhibitors - a cross-sectional study in pakistan
Abstract
Objective: Proton Pump Inhibitors (PPIs) constitute a widely prescribed class of medications for gastroesophageal reflux disease and related conditions. Despite their prevalent usage, there exists a knowledge gap regarding patient demographics, usage patterns, and associated health behaviors. The objective of the study was to identify the side effects experienced by the users taking PPIs as well as the awareness about these side effects. Methodology: A cross-sectional study involving 404 participants was conducted between April to December 2023 in Rawalpindi, Pakistan. Data were collected using a structured questionnaire focused on demographics, PPIs usage patterns, knowledge levels, awareness of side effects, and reported adverse events. Results: PPIs usage patterns indicated variations in the duration of therapy, raising questions about the appropriateness of prolonged use. The most common side effect reported in our population was bloating in 82.4% of population, followed by iron deficiency anemia (66.6%), headache (61.4%), osteoporosis (52.2%), and constipation (46.0%). Additionally, 33.9% and 30.7% of individuals had dementia and fracture risk. However, awareness about PPIs side effects was very limited with only 10.6% of participants knew about short-term PPIs side effects, while majority of the participants (69.8%) were unaware of long-term PPIs side effects. Health behavior exploration uncovered notable prevalence rates of non-smokers and non-alcoholics, shedding…
How strong is the evidence?
Evidence Hub reads this as a cross-sectional, done in people. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause. Reported size: 404 participants or records.
Read the paper
Related studies
- Improving sleep quality leads to better mental health: A meta-analysis of randomised controlled trials
- Tocilizumab in patients with severe COVID-19: a retrospective cohort study
- A new aging measure captures morbidity and mortality risk across diverse subpopulations from NHANES IV: A cohort study
- Fruit, vegetable, and legume intake, and cardiovascular disease and deaths in 18 countries (PURE): a prospective cohort study
- Are noise and air pollution related to the incidence of dementia? A cohort study in London, England
- Long COVID symptoms and duration in SARS-CoV-2 positive children — a nationwide cohort study
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.