Evaluating the Efficacy and Safety of Concurrent Proton Pump Inhibitors and Clopidogrel Therapy in post-PCI Patients: A Comprehensive Systematic Review and Network Meta-Analysis
Abstract
eview question / Objective To investigate the MACEs risk of clopidogrel combined with PPIs.Rationale Clopidogrel, a critical medication for managing patients post-percutaneous coronary intervention (PCI), acts as an antiplatelet agent.A notable side effect of clopidogrel includes gastrointestinal (GI) bleeding.To mitigate this, the use of proton pump inhibitors (PPIs) like esomeprazole, lansoprazole, pantoprazole, omeprazole, and rabeprazole is common.Nevertheless, concerns regarding possible interactions between clopidogrel and PPIs have emerged.The objective of our research is to identify which PPIs, when used in combination with clopidogrel, present the least risk of major adverse cardiovascular events (MACEs) and GI bleeding. Condition being studiedThe PICO (population, intervention, comparison, outcome) setting of the current meta-analysis included: (1) P: human participants with post-PCI using clopidogrel; (2) I: co-administrated PPI; (3) C: placebo group without intervention; and (4) O: MACEsrisk. METHODS Participant or population Human participants. Intervention PPIs combination.Comparator Placebo.Study designs to be included Randomized controlled trials and cohort studies. Eligibility criteriaThe criteria for selecting studies to be included in our research are as follows: (1) Randomized controlled trials and retrospective cohort studies involving patients who underwent
How strong is the evidence?
Evidence Hub reads this as a meta-analysis, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid.
Read the paper
Related studies
- Improving sleep quality leads to better mental health: A meta-analysis of randomised controlled trials
- Tocilizumab in patients with severe COVID-19: a retrospective cohort study
- A new aging measure captures morbidity and mortality risk across diverse subpopulations from NHANES IV: A cohort study
- Fruit, vegetable, and legume intake, and cardiovascular disease and deaths in 18 countries (PURE): a prospective cohort study
- Are noise and air pollution related to the incidence of dementia? A cohort study in London, England
- Long COVID symptoms and duration in SARS-CoV-2 positive children — a nationwide cohort study
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.