Concomitant use of metformin and proton pump inhibitors increases vitamin B12 deficiency risk in type 2 diabetes
Abstract
INTRODUCTION: Vitamin B12 deficiency is one of the adverse drug reactions of metformin and proton pump inhibitors (PPIs). As symptoms of gastroesophageal reflux disease are frequently reported in patients with diabetes, the concomitant use of metformin and PPI is expected. Therefore, this study aimed to investigate the effects of concurrent PPI use on the risk of vitamin B12 deficiency in patients with type 2 diabetes (T2DM) using metformin. MATERIALS AND METHODS: This retrospective cohort study was conducted using a sample cohort database provided by the National Health Insurance Service. Among adult patients newly diagnosed with T2DM, new users of metformin who used metformin ≥4 months were included. The subjects were divided into two cohorts: metformin monotherapy and metformin + PPI. Vitamin B12 deficiency was defined by a diagnostic code or a prescription of medications for vitamin B12 supplementation. A Cox proportional hazards model was used to estimate the adjusted hazard ratio (aHR) with a 95% confidence interval (CI). RESULTS: In total, 11,200 subjects were included in the 1:1 propensity score-matched cohort. The risk of vitamin B12 deficiency was significantly higher in the metformin + PPI cohort compared with the metformin monotherapy cohort (aHR, 1.18; 95% CI, 1.02-1.35). CONCLUSIONS: A significant association between the concurrent use of metformin and PPI and an increased risk of vitamin B12 deficiency was found, highlighting the need to carefully monitor the…
How strong is the evidence?
Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 11,200 participants or records.
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