A Review on Development and Validation for the Simultaneous Estimation of Lansoprazole and Domperidone in Bulk and Capsule Dosage Form
Abstract
Lansoprazole is an effective proton pump inhibitor utilized for managing various acid-related disorders, such as ulcers and gastroesophageal reflux disease (GERD), by significantly reducing stomach acid production. It has demonstrated a general tolerance among users, with common side effects including headaches, nausea, and diarrhea, while serious side effects are comparatively rare. Importantly, lansoprazole may provide superior healing results for conditions like ulcers and esophagitis compared to alternative medications such as ranitidine. Furthermore, it plays a key role in eradicating Helicobacter pylori bacteria when used in combination with antibiotics. Domperidone is a dopamine antagonist primarily used to treat nausea, vomiting, and gastrointestinal motility disorders. It functions both as an antiemetic, alleviating symptoms of nausea and vomiting, and as a prokinetic agent, enhancing gastric emptying. Notably, it is regarded as safer compared to metoclopramide due to its limited ability to cross the blood-brain barrier, thus minimizing central nervous system side effects. However, its safety profile is under scrutiny, particularly concerning potential cardiac effects and its impact on mental health during lactation. The future scope for the simultaneous estimation of Lansoprazole (LAN) and Domperidone (DOM) emphasizes the development of efficient, sustainable, and high-throughput analytical methods. Key areas of focus include minimizing hazardous solvent use…
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