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Long-term integrative personalized medicine care in massive brainstem hemorrhage: A CARE-compliant case report

Lee YV, Ahn J, Lee E, Park C, Son EJ, Jeong JY

Medicine, 2026

Abstract

Rationale: Brainstem hemorrhage is a rare but devastating subtype of intracerebral hemorrhage that frequently presents with impaired consciousness, quadriplegia, and recurrent infections. Integrative personalized medicine care (IPMC), which combines essential conventional treatments with personalized traditional Korean medicine interventions, has been suggested to improve functional outcomes and support immune regulation. By closely monitoring a patient with massive brainstem hemorrhage treated with IPMC, we observed neurological improvement, effective control of recurrent infections and inflammation, and sustained safety of long-term herbal medications.

Patient concerns: A 48-year-old female patient with a brainstem hemorrhage was managed at Kyung Hee University Hospital with IPMC for posthemorrhagic functional impairment and recurrent infection.

Diagnoses: The patient was diagnosed with a massive pontine hemorrhage with posthemorrhagic functional impairment and recurrent infection.

Interventions: The patient received conventional treatment and integrative personalized traditional Korean medicine interventions, including herbal medications and acupuncture.

Outcomes: We retrospectively analyzed the 2-year clinical course of the patient who received IPMC to evaluate the efficacy and safety of the treatment. Functional outcomes and inflammation control were assessed using standardized scales (modified Barthel index, Korean mini-mental state examination, Glasgow Coma Scale,…

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