The Efficacy of Bacteriophage Therapy in Orthopaedic Field: A Systematic Review
Abstract
INTRODUCTION: Bacterial infections are the cause of high mortality rates in the world. Antibiotics and multidrug work well together to treat the patient. The pathogens are harder to control and develop antibiotics resistance. In orthopaedic field, infections like osteomyelitis, septic arthritis, or infections of the bone, joints, or implants (periprosthetic joint infections [PJI]) can be difficult to resolve both microbiologically and clinically. Bacterial viruses (bacteriophages) are one possible substitute. Due to their great host specificity, lack of adverse effects, and safety for eukaryotic cells, these viruses provide novel advantages, such as the safe treatment of illnesses. MATERIAL AND METHODS: Three databases were used for the bibliographical search: Google Scholar, PubMed, and ScienceDirect for case report related to bacteriophage therapy and antibiotic resistance in orthopaedics, which were published between 2014 and 2024, which based on PRISMA guidelines qualified 10 articles for systematic review. RESULT: In orthopaedic cases biofilm formation is widely recognized as the main obstacle to effective prevention and treatment. Biofilm production is intimately related to bacteria's capacity to create chronic illnesses and the challenge of overcoming them. The biofilm-disrupting properties of certain phages make them a promising option for managing device-associated infections. The capacity of phages to enter a biofilm and then cling to the surface of the host…
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