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The Medical Management of Interstitial Pregnancy: A Case Series and Literature Review

Billie Frederix, Martine Dehandschutter, F. Buxant

Case Reports and Reviews, 2025

Abstract

Introduction: Interstitial pregnancies are a rare form of ectopic pregnancy, and their diagnosis and

treatment can be challenging.

Results: This case series presents three cases of interstitial pregnancies successfully treated with

intramuscular methotrexate.

Conclusion: Methotrexate is an effective treatment for interstitial pregnancies, even in cases with high

β-hCG levels or fetal cardiac activity. For patients who can be closely monitored, medical treatment

provides a good alternative to surgery.

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