Genotype-tailored Treatment of Symptomatic Acid-Reflux in Children With Uncontrolled Asthma
Abstract
This study will evaluate the effect of CYP2C19 and ABCB1 genes on pharmacokinetics of lansoprazole in children with mild gastroesophageal reflux (GER) and uncontrolled asthma. It will determine if genotype-guided lansoprazole dosing of lansoprazole improves GER and asthma control.
Conditions: Asthma, Gastroesophageal Reflux.
Primary outcome: Change in Asthma Control Questionnaire (ACQ) From Screening Through Week 26.
Enrollment: 41 participants.
How strong is the evidence?
Evidence Hub reads this as a clinical trial, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 41 participants or records.
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