Method Development Technology and Optimisation Studies in Famotidine Pellets: An In Vitro Release
Abstract
Oral medication administration has long been the most convenient and widely utilized technique of drug administration. Pellets are fine powders or granules of bulk pharmaceuticals and excipients agglomerated together. They are made up of tiny, free-flowing spherical or semi-spherical solid units that range in size from 0.5 to 1.5mm. These are normally meant to be taken by mouth. Thus, Famotidine has been chosen to prepare pellet formulations employing polymers such as HPMC, Eudragit, and HPC in this study. To analyze and estimate the drug in buffers and acid media, calibration curves were constructed using UV at 306 and 286nm respectively. The flow properties like the angle of repose, bulk density, tapped density; Carr’s index, and h-ratio were found to be within the pharmacopeia's guidelines. 12 formulations ranging from F1-F12 were prepared with various concentrations and types of polymers. The drug loading in all the formulations was estimated using HPLC and was found to be satisfactory. The pellets had a smooth surface and uniform drug loading, according to SEM examination. In vitro, drug release tests were conducted, and the F13 and F14 formulations reported the best release based on previous results. The improved formulation was further subjected to release kinetics testing. Formulations are appropriate for releasing medicine into the upper intestine and stomach, according to the research. According to the findings of this investigation, the developed sustained drug…
Read the paper
Related studies
- Improving sleep quality leads to better mental health: A meta-analysis of randomised controlled trials
- Tocilizumab in patients with severe COVID-19: a retrospective cohort study
- A new aging measure captures morbidity and mortality risk across diverse subpopulations from NHANES IV: A cohort study
- Fruit, vegetable, and legume intake, and cardiovascular disease and deaths in 18 countries (PURE): a prospective cohort study
- Are noise and air pollution related to the incidence of dementia? A cohort study in London, England
- Long COVID symptoms and duration in SARS-CoV-2 positive children — a nationwide cohort study
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.