Rapid health technology assessment of tegoprazan in the treatment of acid-related diseases
Abstract
Abstract Objectives To evaluate the efficacy, safety, and cost-effectiveness of tegoprazan in the treatment of acid-related diseases and to provide evidence-based support for clinical rational drug use. Methods PubMed, Embase, Web of Science, Cochrane Library, CNKI, Wanfang Data, VIP and official websites of foreign health technology assessment institutions were systematically searched from inception to December 2025. Two reviewers independently screened, extracted, and assessed the quality of included studies according to the inclusion and exclusion criteria, and performed qualitative description and analysis. Results A total of 10 studies were included, comprising 9 systematic reviews/meta-analyses and 1 pharmacoeconomic study. In terms of efficacy, tegoprazan and proton pump inhibitors (PPIs) demonstrated similar efficacy and good compliance in the treatment of erosive esophagitis and Helicobacter pylori infection. Subgroup analyses showed higher eradication rates in studies conducted in China, those with treatment durations of 10 or 14 days, those using dual or bismuth quadruple regimens, and in patients with clarithromycin-resistant strains. In terms of safety, both tegoprazan and PPIs exhibited comparable safety profiles. Tegoprazan was associated with a significantly lower incidence of adverse effects such as abdominal pain, abdominal bloating, diarrhea, headache, and taste disorders compared to PPIs, while it increased the risk of liver function abnormalities.…
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