Efficacy of Potassium-Competitive Acid Blockers Versus Proton Pump Inhibitors for Gastric Ulcers: Bayesian and Frequentist Network Meta-Analysis With Cross-Inference Through a Quality management System
Abstract
• Our study group conducted a systematic review and network meta-analysis (NMA) comparing the efficacy of potassium-competitive acid blockers (P-CABs) and proton pump inhibitors (PPIs) in treating gastric ulcer (GU) based on randomized controlled trials. • We first present the results of Bayesian + frequentist NMA backbones with cross-inference with the purpose of grouping between P-CABs and PPIs. • We found that the results of the Bayesian + frequentist NMA and grouped inference framework showed similar trends. • Compared to PPIs, our study showed that the cure rates in GU managed with P-CABs were non-inferior. • We also summarized the P-CABs’ current status and characteristics in the discussion section. Proton pump inhibitors (PPIs) have been the mainstay treatment for gastric ulcer (GU) for over 30 years. However, since the discovery of a new class of acid suppressants, potassium-competitive acid blockers (P-CABs), the desire for a therapeutic agent has continued and the clinical trials on P-CABs have been conducted. In this regard, we aimed to assess whether P-CABs are noninferior to PPIs in patients with GU in terms of efficacy. We performed a systematic review and network meta-analysis (NMA) based on randomized controlled trials (RCTs). Additionally, we used a new methodology of inference concept with the purpose of grouping between P-CABs and PPIs. Moreover, our quality management system was integrated throughout the research to ensure data accuracy. We initially…
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Evidence Hub reads this as a meta-analysis, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid. Reported size: 6,315 participants or records.
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