Advances in Peptic Ulcer Treatment: Role of Vonoprazan, Tegoprazan, Keverprazan, and Anaprazole
Abstract
Background: Peptic ulcer disease (PUD) is a common gastrointestinal disorder frequently caused by Helicobacter pylori (H. pylori) infection or the use of non-steroidal anti-inflammatory drugs. It is associated with significant morbidity, particularly when complicated by upper gastrointestinal bleeding. Proton pump inhibitors have long been the standard of care for acid suppression. However, they have limitations, including delayed onset of action, food dependency, and variability in metabolism influenced by genetic polymorphisms. Objective: This review evaluates the comparative efficacy and safety of novel acid-suppressing agents, including potassium-competitive acid blockers such as vonoprazan, tegoprazan, and keverprazan, as well as anaprazole, a structurally modified proton pump inhibitor. Methodology: Findings from several phase three randomized controlled trials were analyzed. These trials compared newer agents with traditional proton pump inhibitors in terms of ulcer healing, symptom relief, rebleeding prevention, and tolerability. Results: Vonoprazan was shown to be as effective as intravenous pantoprazole in preventing rebleeding after endoscopic hemostasis. Tegoprazan and keverprazan achieved similar or superior healing rates compared to lansoprazole. Anaprazole showed consistent efficacy with reduced variability due to its partial non-enzymatic metabolism. Conclusion: These emerging therapies offer promising alternatives by providing more consistent acid…
Read the paper
Related studies
- Prevalence and Characteristics of Autism Spectrum Disorder Among Children Aged 8 Years — Autism and Developmental Disabilities Monitoring Network, 11 Sites, United States, 2018
- Improving sleep quality leads to better mental health: A meta-analysis of randomised controlled trials
- Community transmission and viral load kinetics of the SARS-CoV-2 delta (B.1.617.2) variant in vaccinated and unvaccinated individuals in the UK: a prospective, longitudinal, cohort study
- Occupation and risk of severe COVID-19: prospective cohort study of 120,075 UK Biobank participants
- Clinical presentation and virological assessment of confirmed human monkeypox virus cases in Spain: a prospective observational cohort study
- Comparison of the characteristics, morbidity, and mortality of COVID-19 and seasonal influenza: a nationwide, population-based retrospective cohort study
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.