Non-inferiority of Tegoprazan to PPIs in H. pylori Eradication: Systematic Review and Meta-analysis
Abstract
Aims Helicobacter pylori infection contributes to peptic ulcer disease and gastric cancer, making eradication crucial. However, standard therapy with a proton pump inhibitor (PPI) plus antibiotics has shown declining success rates. Tegoprazan is a novel potassium-competitive acid blocker (P-CAB) that producing rapid, meal-independent and CYP2C19-genotype–independent acid suppression. We performed a meta-analysis to compare the efficacy and safety of tegoprazan-based regimens versus PPI-based regimens for H. pylori eradication Methods We systematically searched PubMed, Scopus, Cochrane Library and Web of Science. Eligible randomized and comparative studies evaluated tegoprazan-based versus PPI-based regimens. The primary endpoint was intention-to-treat (ITT) eradication; secondary endpoint was overall adverse events (AEs). Random-effects meta-analysis pooled risk ratios (RR) with 95% confidence intervals (CI); heterogeneity was assessed with I². Prespecified subgroup analyses were by treatment regimen (triple, dual, other). Results Eleven studies met inclusion criteria. Eradication efficacy was equivalent between groups (RR 1.01, 95% CI 0.96–1.05, p=0.77; I²=0%). Subgroups showed no effect modification: triple RR 1.00 (0.92–1.08; I²=0%), dual RR 1.02 (0.93–1.12; I²=0%), other RR 1.01 (0.93–1.09; I²=0%). AEs were similar overall (RR 0.92, 0.82–1.03; p=0.15; I²=29.7%, τ²=0.01). By regimen, dual therapy favored tegoprazan with fewer AEs (RR 0.68, 0.53–0.89; I²=0%; p=0.005),…
How strong is the evidence?
Evidence Hub reads this as a meta-analysis. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid.
Read the paper
Related studies
- Prevalence and Characteristics of Autism Spectrum Disorder Among Children Aged 8 Years — Autism and Developmental Disabilities Monitoring Network, 11 Sites, United States, 2018
- Improving sleep quality leads to better mental health: A meta-analysis of randomised controlled trials
- Community transmission and viral load kinetics of the SARS-CoV-2 delta (B.1.617.2) variant in vaccinated and unvaccinated individuals in the UK: a prospective, longitudinal, cohort study
- Occupation and risk of severe COVID-19: prospective cohort study of 120,075 UK Biobank participants
- Clinical presentation and virological assessment of confirmed human monkeypox virus cases in Spain: a prospective observational cohort study
- Comparison of the characteristics, morbidity, and mortality of COVID-19 and seasonal influenza: a nationwide, population-based retrospective cohort study
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.