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A Practical Green Synthesis of ( R )-5,7-difluorochroman-4-ol, a Key Intermediate of Tegoprazan

Haiping Zhou, Hao Xuan Sun, Wenwen Yang, Zongjie Gan

Organic Preparations and Procedures International, 2024

3 citations

Abstract

Tegoprazan (trade name K-CAB®, Figure 1), namely (S)-4-((5,7-difluorochroman-4-yl) oxy)-N, N, 2-trimethyl-1H-benzo[d]imidazole-6-carboxamide, is a potassium-competitive acid blocker (P-CAB) for the...

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