Potassium-Competitive Acid Blocker–Based Triple Therapy versus Proton Pump Inhibitor–Based Triple Therapy for Helicobacter pylori Eradication: A Systematic Review and Meta-analysis of Randomized Controlled Trials
Abstract
Introduction: Gastric acid secretion is strongly and persistently inhibited by potassium competitive acid blocker (P-CAB). The safety and effectiveness of P-CAB-based triple therapy versus conventional proton pump inhibitor (PPI)-based triple therapy for eradication of Helicobacter pylori have been examined in a number of studies, however the outcomes are still inconsistent. To assess the safety, treatment compliance/adherence, and effectiveness of P-CAB-based triple therapy in comparison to PPIbased triple therapy for the eradication of H. pylori, we have conducted this systematic review and meta-analysis.
Methods: The PRISMA 2020 requirements for systematic review and meta-analysis were adhered to. Randomized controlled trials (RCTs) comparing P-CAB-based triple therapy with PPI-based triple therapy (PTT) for H. pylori eradication that were published between February 2015 and February 2026 were found by searching MEDLINE, Embase, and the Cochrane Library. Informations were gathered on treatment compliance/adherence, adverse drug reactions, and the eradication rates (intentionto-treat analysis). Pooled risk ratios (RR) at 95% confidence intervals (CI) were computed using Review Manager.
Results: The analysis includes eight randomized controlled trials (RCTs) with 2378 individuals. Six RCTs evaluated vonoprazanbased triple therapy (VTT), while two RCTs assessed tegoprazan-based triple therapy (TTT). Pooled analysis of six RCTs (1780 patients) evaluating VTT showed…
How strong is the evidence?
Evidence Hub reads this as a meta-analysis, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid. Reported size: 2,378 participants or records.
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