Editorial: proton pump inhibition – microbial complications beyond dysbiosis
Abstract
© 2019 John Wiley & Sons Ltd 6. Yu K‐S, Bae K‐S, Shon J‐H, et al. Pharmacokinetic and pharmaco‐ dynamic evaluation of a novel proton pump inhibitor, YH1885, in healthy volunteers. J Clin Pharmacol. 2004;44:73‐82. 7. Jenkins H, Sakurai Y, Nishimura A, et al. Randomised clinical trial: safety, tolerability, pharmacokinetics and pharmacodynamics of re‐ peated doses of TAK‐438 (vonoprazan), a novel potassium‐compet‐ itive acid blocker, in healthy male subjects. Aliment Pharmacol Ther. 2015;41:636‐648. 8. Han S, Choi HY, Kim YH, et al. Randomised clinical trial: safety, tolerability, pharmacokinetics, and pharmacodynamics of single and multiple oral doses of tegoprazan (CJ‐12420), a novel potas‐ sium‐competitive acid blocker, in healthy male subjects. Aliment Pharmacol Ther. 2019;50:751‐759. 9. Sunwoo J, Oh J, Moon SJ, et al. Safety, tolerability, pharmaco‐ dynamics and pharmacokinetics of DWP14012, a novel potas‐ sium‐competitive acid blocker, in healthy male subjects. Aliment Pharmacol Ther. 2018;48:206‐218. 10. Graham DY, Dore MP. Update on the use of vonoprazan: a compet‐ itive acid blocker. Gastroenterology. 2018;154:462‐466.
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Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design.
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