A multidirectional effect of metformin
Abstract
Diabetes as chronic civilization disease, very often occurs together with health disorders. One of the basic pharmaceuticals commonly used in her therapy is metformin. Many other positive effects, not related to diabetes, have been observed in tatients treated with metformin for a long time. These are: positive changes in diagnostiic parameters, protection against cancer development, less frequent occurrence of other pathologies and diseases, increased sensitivity to selected drugs (e.g. cytostatics), delayed aging processes of organism. In addition to the molecular changes resulting in a hypoglycemic effect, the most common modifications of gene expression have been described, indicated as the basis for the anti-aging, anti-atherosclerotic and anticancer effects of this drug and its effect on melanogenesis or the nervous system. The results presented in the study are very promising, but most of them relate to experiments carried out in cell cultures or animals. The possibility of obtaining similar effects in humans requires much more research.
How strong is the evidence?
Evidence Hub reads this as a review, done in animal, not in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
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