Overcoming barriers to the use of metformin: patient and provider perspectives
Abstract
BACKGROUND: Metformin is the first-line treatment for type 2 diabetes mellitus. Observational studies show lower rates of use than would be expected from clinical guidelines. OBJECTIVE: We undertook a qualitative study of barriers to metformin use from the patient and provider perspective. DESIGN: Patient focus group, patient individual interviews, provider interviews, and chart review. Purposive sampling of patients and providers in New York State. PARTICIPANTS: Seven one-on-one patient interviews, one focus group with 13 patients, 10 provider interviews, and manual review of 1259 charts. APPROACH: Grounded theory. RESULTS: Both providers and patients cited potential health benefits as strong reasons to take metformin and describe it as the first-line drug for diabetes. Patients and providers both cited gastrointestinal side effects as the primary barrier to metformin use. Patients described adapting to these side effects and taking metformin at a time that minimizes them. In contrast, providers emphasized dose titration and the use of extended-release formulation as tools for minimizing side effects but were uncertain about the effectiveness of these strategies. CONCLUSION: Metformin is positively viewed by patients and providers, but gastrointestinal side effects are a barrier to its use. There is some consensus on basic measures to improve its tolerability, but these measures are not consistently applied and lack evidence establishing their effectiveness. Pragmatic…
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