In silico study for screening of natural phytochemicals and metformin as a potential inhibitor of interleukin 6 as target for covid-19
Abstract
Interleukin 6 is considered the corner stone at treatment of covid-19 specially the severe cases and it is the marker of severe inflammation and the gate of cytokine storm , so the future studies for this important proinflammatory cytokine storm , the first target for speed recovery from sars cov2 it is overcoming this cytokine which is immune response to virus , it is responsible about the fever and most sypmtoms of severity of covid-19 also may has role at smell and taste , so this study target this interleukin-6 by discovering natural potential inhibitors of IL-6. We do molecular docking for some natural phytochemicals like EGCG , bromelain , luteolin , vitexin and isovitexin , in adding to metformin and polyetheylene glycocl
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Evidence Hub reads this as a dataset, done in computer models (in silico), not in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
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