Vonoprazan in erosive esophagitis: Influence of gender and hiatus hernia on outcomes
Abstract
Objective: This study aimed to determine the efficacy of vonoprazan in erosive esophagitis and association of gender and hiatus hernia with treatment outcomes.
Methodology: This prospective single arm cohort study (before and after treatment) was conducted from 1st January to 31st August 2025 in Department of Gastroenterology, HMC Peshawar. Non-probability convenience sampling technique was used. Total 220 patients with endoscopically confirmed erosive esophagitis (EE) and fulfilling inclusion criteria were included. Exclusion criteria included peptic ulcer disease, malignancy, prior gastrointestinal surgery, pregnancy and recent NSAID use. All patients received vonoprazan 20-mg once daily for Eight weeks. Demographic and clinical data were documented. Endoscopic evaluation was repeated post-treatment. Data was analyzed using descriptive statistics, with p < 0.05 considered statistically significant.
Results: The mean age was 42.51±8.19 years, with 120 (54.5%) male and 100 (45.5%) female. Before treatment, 115(52.3%) had LA-C and 26(11.8%) had LA-D esophagitis. Following treatment, 191(86.8%) out of 220 patients had no esophagitis, 18(8.2%) had LA-A and 11(5%) had LA-B esophagitis (OR:6.59, 95%CI 4.45 - 9.73, p < 0.001). Complete healing rates were similar in male and female patients (p = 0.94). Among 58 patients having hiatus hernia, 35(60.34%) had no esophagitis post-treatment as compared to those without hernia where 156 out of 162 (96.29%) had no esophagitis…
How strong is the evidence?
Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 220 participants or records.
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