Real-world pharmacological treatment of patients with hyperemesis gravidarum in 9 cities of China from 2019 to 2024: a cross-sectional analysis
Abstract
Objective: Analyze the trends and utilization patterns of medicine for hyperemesis gravidarum (HG) in nine Chinese cities over the past 6 years to provide a reference for clinical practice.
Method: The prescription data of drugs for patients diagnosed with HG from 2019-2024 were obtained from the Hospital Prescription Analysis Cooperation Project database of the Hospital Pharmacy Professional Committee of Chinese Pharmaceutical Association. A cross-sectional analysis was then performed of demographic characteristics, medication types, defined daily doses (DDDs), defined daily costs (DDC), combination therapy and comorbidities for HG.
Results: A total of 9097 patients diagnosed with HG, involving 12,505 prescriptions, with a mean age of 29.97 ± 4.35 years. The number of patients in new first-tier cities (Chengdu, Hangzhou, Shenyang, Zhengzhou) exhibited a significant increase. The proportion of advanced maternal age and ≥16 weeks patients has significantly increased. Vitamin B6, metoclopramide, omeprazole, hydrated magnesium hydroxide, and aluminum ranked highest in terms of DDDs. 87% of patients required hospitalization, where combination therapy was commonly observed, predominantly antiemetics combined with antacids/acid reducers. Total prescription costs and per capita costs decreased by 42.71% and 55.63% respectively. The gradual decline in the DDC of PPIs and 5-HT3 antagonists may be associated with the implementation of national centralized drug procurement in China.…
How strong is the evidence?
Evidence Hub reads this as a cross-sectional, done in people. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause. Reported size: 9,097 participants or records.
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