Vonoprazan vs. Lansoprazole for the treatment of endoscopic submucosal dissection induced gastric ulcer: a systematic review and meta-analysis
Abstract
BACKGROUND
Vonoprazan is a potassium competitive acid blocker (P-CAB) approved in Japan in 2014 to treat endoscopic submucosal dissection (ESD)-induced ulcer and bleeding perforation, and this meta-analysis is to compare whether Vonoprazan is more effective than lansoprazole in the treatment of ESD-induced ulcers (including ulcer healing , shrinking rate and so on).
METHODS
Collected randomized controlled trials (RCT) and retrospective studies from the PubMed (Medline), Embase, Web of science, and Cochrane Library databases that discussed the effectiveness of Vonoprazan and lansoprazole on ESD-induced ulcers. Studies were selected according to predetermined qualification criteria and data were extracted by two researchers. We evaluated the quality of the methods for published papers using the modified Jadad scale.
RESULTS
There were five studies included in this meta-analysis, the ulcer healing rate effect was not significantly higher in the intervention groups than in the control groups at 4 weeks, [OR：1.07 (0.51, 2.22), 95% CI, I2=2%, Z=0.18, P=0.86]. The ulcer shrinkage rate was not significantly higher than the control group at 4 weeks, [MD：0.20 (-1.51, 1.92), 95% CI, I2=0%, P=0.82]. The ulcer shrinkage rate was not significantly higher than the control group at 8 weeks, [MD: -0.09 (-0.30, 0.12), 95% CI, I2=0%, P=0.39].
CONCLUSION
There were no significant difference between Vonoprazan and lansoprazole in the ulcers induced by treatment at 4 weeks and 8 weeks after…
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Evidence Hub reads this as a meta-analysis, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid.
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