Eradication of Helicobacter pylori infection in Hungary (1993-2002): a meta-analysis
Abstract
INTRODUCTION: Meta-analysis is a useful tool in obtaining sound data in evidence-based medicine. The guidelines of eradication have been proposed in the I. Maastricht consensus (1996), which was modified in 2000.
AIM OF STUDY: The scope of present paper is the meta-analysis of eradication studies performed in Hungary between 1993-2002.
METHODS: Articles/abstracts dealing with eradication, published in peer-reviewed Hungarian and international journals, meetings of the Hungarian Society of Gastroenterology and its Endoscopic Section and international congresses were identified from major databases and by manual search. The data were classified into groups based on eradication schedules, type of antibiotic used, and provenience of the study. The pooled eradication rates were calculated and compared with the international data.
RESULTS: The pooled eradication rate of proton pump inhibitor-based triple therapies was 82.9% (confidence interval: 72.1-93.7%); omeprazole, pantoprazole and lansoprazole-based therapies given b.i.d. were equally efficient. H2-blockers based triple combinations lasting 10-14 days obtained a pooled eradication rate of 86.3% (confidence interval: 72.2-99.8%), insignificantly higher (p = 0.07) than the rate obtained with proton pump inhibitors. Classical triple therapy's (bismuth + 2 antimicrobials) pooled eradication rate is significantly lower as that of proton pump inhibitor (p = 0.01) or H2 blocker-based combinations (p = 0.008). Clarithromycin,…
How strong is the evidence?
Evidence Hub reads this as a meta-analysis, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid.
Read the paper
Related studies
- The Prediction of the In Vitro Release Curves for PLGA-Based Drug Delivery Systems with Neural Networks
- Promising Ursolic Acid as a Novel Antituberculosis Agent: Current Progress and Challenges
- Proof of principle concept for the analysis and functional prediction of rare genetic variants in the CYP2C19 and CYP2D6 genes
- Fabrication, characterization, and docking studies of furosemide-loaded nanosponges using the emulsion solvent diffusion method
- The Effect of Concomitant Administration of Proton Pump Inhibitors on the Pharmacokinetics of CDK4/6 Inhibitors in Rats: Implications for the Evaluation of Hepatic and Transporter-Mediated Drug–Drug Interactions
- Mining the Metabolic Capacity of Clostridium sporogenes Aided by Machine Learning
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.