Preclinical evidence of the therapeutic effect of Moringa oleifera in peptic ulcer disease: a systematic review and meta-analysis
Abstract
Background: Peptic ulcer disease (PUD) remains a global health burden, with current therapies limited by recurrence, adverse effects, and high costs. Moringa oleifera, a medicinal plant traditionally used for gastrointestinal disorders, has shown anti-ulcer potential in several experimental models. However, no systematic synthesis has consolidated the available preclinical evidence. This review evaluated the therapeutic efficacy of M. oleifera in PUD using evidence from preclinical (rodent) studies.
Materials and methods: We searched PubMed, CINAHL, Scopus, Web of Science, and the Cochrane Library from inception (without time filter) to August 2025. Eligible studies were randomized controlled animal experiments assessing M. oleifera extracts in ulcer-induced models. Data on ulcer index were extracted, and a random-effects meta-analysis was performed using Hedge's g to calculate standard mean difference (SMD). Heterogeneity was assessed with I2, and publication bias with Egger's regression and trim-and-fill methods.
Results: Eleven (11) studies involving 268 animals met the inclusion criteria, with SYRCLE quality scores ranging from 8 to 9. Pooled analysis showed that M. oleifera significantly reduced ulcer index compared with controls (SMD = -1.42; 95% CI: -2.01 to -0.83; p 2 = 69%), while comparisons with basal controls also lacked significance (SMD = 0.99; 95% CI: 0.24-2.22; p = 0.11). Sensitivity analyses resolved heterogeneity (I2 = 0%) and publication bias, without…
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Evidence Hub reads this as a meta-analysis. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid.
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