Treatment for Laryngopharyngeal Reflux Disease: A Systematic Review of Controlled Studies
Abstract
ImportanceProton pump inhibitors (PPIs) do not demonstrate superiority over placebo in laryngopharyngeal reflux disease (LPRD). While poorly used, many alternative medical treatments exist for controlling the gastroduodenal and gastro-pharyngeal reflux processes.ObjectiveTo investigate the clinical findings of controlled studies comparing therapeutic regimens for treating LPRD.DesignPubMED, Scopus, and Cochrane Library systematic review without meta-analysis using the PRISMA statements.SettingReview of prospective or retrospective cohort studies comparing 2 medical regimens in patients with suspected or confirmed LPRD.ParticipantsPatients with suspected or confirmed LPRD.InterventionComparison of PPI therapy to other therapeutic regimens for LPRD.OutcomesSymptom, sign changes, and therapeutic responses were considered from pre- to posttreatment. Bias analysis was conducted with Methodological Index for Non-Randomized Studies (MINORS). Implications for practice were summarized with a focus on the pharmacological and biological findings of all drug classes in the LPRD pathophysiology.ResultsFourteen studies met the inclusion criteria, including 1269 patients. There were 675 females (59.6%) and 458 males (40.4%). The mean age of patients was 49.1 years. Substantial variability was observed among studies regarding both pharmacological interventions and participant selection criteria. Two of the four comparative studies demonstrated superior therapeutic efficacy with…
How strong is the evidence?
Evidence Hub reads this as a systematic review, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid. Reported size: 1,269 participants or records.
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