New triple therapy for Helicobacter pylori infection in Japan
Abstract
In Japan, a phase 3 trial of 1-week triple therapy with lansoprazole(L), amoxicillin(A), and clarithromycin(C) was finished in March, 2000. Patients were randomized into three groups: L 30 mg bid and placebos, and L 30 mg bid, A 750 mg bid and C 200 mg bid or 400 mg bid. Eradication rates were high in group LAC200(88-91%) and group LAC400 (84-89%). Next, a phase 3 trial of 1-week triple therapy with omeplazole (O), A and C was finished in 2001. Eradication rates were 78.8% in the group of O 20 mg, A 750 mg and C 400 mg bid, and 83.0% in the group of O 20 mg, A 1,000 mg, and C 500 mg bid.
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design.
Read the paper
Related studies
- The Prediction of the In Vitro Release Curves for PLGA-Based Drug Delivery Systems with Neural Networks
- Promising Ursolic Acid as a Novel Antituberculosis Agent: Current Progress and Challenges
- Proof of principle concept for the analysis and functional prediction of rare genetic variants in the CYP2C19 and CYP2D6 genes
- Fabrication, characterization, and docking studies of furosemide-loaded nanosponges using the emulsion solvent diffusion method
- The Effect of Concomitant Administration of Proton Pump Inhibitors on the Pharmacokinetics of CDK4/6 Inhibitors in Rats: Implications for the Evaluation of Hepatic and Transporter-Mediated Drug–Drug Interactions
- Mining the Metabolic Capacity of Clostridium sporogenes Aided by Machine Learning
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.