Omeprazole vs. Lansoprazole: Effectiveness in gastroesophageal reflux disease patients at a Jambi Referral Hospital
Abstract
Background: Omeprazole and lansoprazole, both proton pump inhibitors (PPIs), are widely used to manage gastroesophageal reflux disease (GERD) with comparable outcomes. However, lansoprazole may provide faster symptom relief. This study aimed to compare the clinical effectiveness of omeprazole and lansoprazole in GERD patients.
Method: This observational retrospective cohort study included hospitalized GERD patients at Raden Mattaher Regional Hospital, Jambi, from 2022 to 2024. A total of 117 patients were selected using consecutive sampling. Data were obtained from medical records and analyzed using SPSS version 25.
Results: Most patients were aged 40-59 years (42.7%), female (55.6%), unemployed (55.8%), high school (51.7%), National Health Insurance (93.2%), non-erosive GERD (91.1%), no comorbidities (56.4%), normal BMI (84.2%), average vital signs included blood pressure (130.0 mmHg), pulse (88.0 x/minute), respiration rate (20.0 x/minute), body temperature (36.4°C). The clinical outcome showed negative endoscopic findings (91.1%), length of stay ≤7 days (80.3%) median 5 days. There were no statistically significant differences in clinical improvement between omeprazole and lansoprazole nor type of drug, length of stay, age, gender, grade, occupation or comorbidities (p > 0.05).
Conclusions: The analysis showed no statistically significant difference in clinical outcomes between omeprazole and lansoprazole, indicating comparable effectiveness of both proton pump inhibitors…
How strong is the evidence?
Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 117 participants or records.
Read the paper
Related studies
- The Prediction of the In Vitro Release Curves for PLGA-Based Drug Delivery Systems with Neural Networks
- Promising Ursolic Acid as a Novel Antituberculosis Agent: Current Progress and Challenges
- Proof of principle concept for the analysis and functional prediction of rare genetic variants in the CYP2C19 and CYP2D6 genes
- Fabrication, characterization, and docking studies of furosemide-loaded nanosponges using the emulsion solvent diffusion method
- The Effect of Concomitant Administration of Proton Pump Inhibitors on the Pharmacokinetics of CDK4/6 Inhibitors in Rats: Implications for the Evaluation of Hepatic and Transporter-Mediated Drug–Drug Interactions
- Mining the Metabolic Capacity of Clostridium sporogenes Aided by Machine Learning
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.