Acquired Hemophilia A in an Elderly Patient Receiving Clopidogrel: Drug-Induced or Age-Associated Autoimmunity?
Abstract
Acquired haemophilia A (AHA) is a rare but potentially life-threatening autoimmune bleeding disorder caused by autoantibodies against factor VIII. Its presentation is often non-specific and can mimic more common causes of bleeding, leading to delayed diagnosis, particularly in elderly patients. We report the case of a 93-year-old man with multiple comorbidities who presented with spontaneous, extensive bruising and haemorrhagic complications. Laboratory evaluation demonstrated findings consistent with AHA, including isolated prolongation of the activated partial thromboplastin time (aPTT), reduced factor VIII activity, and the presence of factor VIII inhibitors. The patient received haematology-directed treatment; however, his clinical course was complicated, and he ultimately died. This case highlights the importance of maintaining a high index of suspicion for AHA in elderly patients presenting with unexplained bleeding and emphasises the need for prompt diagnosis and early multidisciplinary management.
How strong is the evidence?
Evidence Hub reads this as a case report, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
Read the paper
Related studies
- The Prediction of the In Vitro Release Curves for PLGA-Based Drug Delivery Systems with Neural Networks
- Promising Ursolic Acid as a Novel Antituberculosis Agent: Current Progress and Challenges
- Proof of principle concept for the analysis and functional prediction of rare genetic variants in the CYP2C19 and CYP2D6 genes
- Fabrication, characterization, and docking studies of furosemide-loaded nanosponges using the emulsion solvent diffusion method
- The Effect of Concomitant Administration of Proton Pump Inhibitors on the Pharmacokinetics of CDK4/6 Inhibitors in Rats: Implications for the Evaluation of Hepatic and Transporter-Mediated Drug–Drug Interactions
- Mining the Metabolic Capacity of Clostridium sporogenes Aided by Machine Learning
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.