Unilateral Ptosis and Bulbar Symptoms as the Initial Presentation of Late-Onset Acetylcholine Receptor Antibody-Positive Myasthenia Gravis Mimicking Acute Ischemic Stroke in an 82-Year-Old Man
Abstract
Myasthenia gravis is an autoimmune disorder of the neuromuscular junction. In older adults, it may present with bulbar and ocular symptoms that resemble acute stroke. Ocular myasthenia is typically asymmetric and often bilateral; persistent unilateral ptosis in this context can be misleading. An 82-year-old man with type 2 diabetes mellitus, chronic kidney disease, cataracts, and macular degeneration presented with a two-week history of fatigable dysphagia, slurred speech, and new-onset unilateral left ptosis. Symptoms were worse towards the end of the day. He denied diplopia and limb weakness. On examination, he was alert with marked left ptosis, mild left facial weakness, and normal limb strength and gait. A working diagnosis of ischemic stroke was made. Computed tomography of the head, magnetic resonance imaging of the brain with magnetic resonance angiography, and carotid Doppler ultrasound showed no acute vascular pathology. Speech and language therapy assessment demonstrated moderately dysarthric but functional speech and a safe swallow using compensatory strategies. ENT review was arranged as a safety assessment to exclude structural lesions or throat pathology in view of his recent swallowing difficulty, sensation of food sticking on the left side, and intermittent nasal speech later in the day; flexible nasal endoscopy was normal. Neurology review noted fluctuating bulbar symptoms with isolated unilateral ptosis, normal extraocular movements, and a normal limb…
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