Subacute cutaneous lupus erythematosus due to proton pump inhibitor intake: case report and literature review
Abstract
Patients with lupus erythematosus (LE) frequently require systemic corticosteroid therapy and some of them also take non-steroidal anti-inflammatory drugs for arthritis or aspirin for thrombosis prevention. However, these drugs, especially if taken concomitantly, may significantly increase the risk of peptic ulcer, and proton-pump inhibitors (PPIs) are currently considered as first line prophylaxis to reduce this risk. The PPIs induce a pronounced and long-lasting reduction of gastric acid production, being the most potent inhibitors of acid secretion available today. In general, PPIs are well tolerated, although some recent reports have raised concerns about the possibility of LE induction due to intake of PPIs [1–6].
Here, we present an additional patient with lansoprazole-induced LE and summarize current literature data on that subject.
A 57-year-old Caucasian woman was admitted to our department with a 2-month history of development of extensive annular, confluent erythemas on the entire body. Three months before skin lesion appearance the patient initiated therapy with lansoprazole due to chronic duodenitis diagnosed on endoscopy. She had no other concomitant diseases and did not take any other drugs.
On admission the patient demonstrated prominent confluent annular erythemas located on the trunk, face, both extremities and V-neck area (Figures 1A--B).B). No other abnormalities were found on physical examination. The patient was in good general condition, but…
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Evidence Hub reads this as a case report, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health. Reported size: 13 participants or records.
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